Posted By: CustomVite Nutrition Team Date: July 13, 2018 Comments: 0

Think all sugar is bad?  You may be surprised to learn that one type of sugar is not so bad for you after all!  In fact, this sugar may help you regain your energy, improve your heart health and improve your body’s cellular performance.  It’s called D-ribose, and it is a simple sugar naturally produced by the body.   Although ribose is classified as sugar, it is metabolized in an entirely different way than other, more familiar sugars, such as glucose, fructose and sucrose.  Furthermore, D-ribose won’t raise your blood sugar or insulin levels and will not contribute to weight gain.  D-ribose is one of the key structural components of ATP (adenosine triphosphate), the source for all cellular energy.  Every cell needs energy (ATP) to carry out its functions, and humans, like all living things, must maintain high levels of ATP to support physical activity.  A depletion of ATP can cause fatigue, exhaustion and can alter your cellular processes and functions.  But what exactly causes ATP depletion?  ATP can be depleted due to decreased oxygen levels, decreased blood flow, inflammation and other stressful conditions like strenuous exercise.

The good news is that D-ribose, one of the key ingredients in ATP, can help maintain optimal ATP levels.  Researchers have found that the more D-ribose is available in the body, the faster ATP levels return to normal.  D-ribose supplementation has been shown to boost heart muscle function following heart attacks, and improve blood circulation in people with congestive heart failure.  It may also help to improve energy levels after a workout, and improve symptoms of disease such as chronic fatigue syndrome, fibromyalgia, restless leg syndrome and coronary artery disease.

Although found naturally, albeit in limited amounts, in certain foods such as red meat, poultry, fish, eggs, nuts, mushrooms and grains, to achieve results found in the research, supplementation may be necessary.





(1) Bayram, M., Cyr, J. S., & Abraham, W. T. (2015). D-Ribose aids heart failure patients with preserved ejection fraction and diastolic dysfunction: A pilot study. Therapeutic Advances in Cardiovascular Disease, 9(3), 56-65. doi:10.1177/1753944715572752

(2) Gebhart, B., & Jorgenson, J. A. (2004). Benefit of Ribose in a Patient with Fibromyalgia. Pharmacotherapy, 24(11), 1646-1648. doi:10.1592/phco.24.16.1646.50957

(3) Hellsten, Y., Skadhauge, L., & Bangsbo, J. (2004). Effect of ribose supplementation on resynthesis of adenine nucleotides after intense intermittent training in humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 286(1). doi:10.1152/ajpregu.00286.2003

(4) Maccarter, D., Vijay, N., Washam, M., Shecterle, L., Sierminski, H., & Cyr, J. S. (2009). D-ribose aids advanced ischemic heart failure patients. International Journal of Cardiology, 137(1), 79-80. doi:10.1016/j.ijcard.2008.05.025

(5) Mahoney, D. E., Hiebert, J. B., Thimmesch, A., Pierce, J. T., Vacek, J. L., Clancy, R. L., . . . Pierce, J. D. (2018). Understanding D-Ribose and Mitochondrial Function. Advances in Bioscience and Clinical Medicine, 6(1), 1. doi:10.7575/aiac.abcmed.v.6n.1p.1

(6) Omran, H., Illien, S., Maccarter, D., Cyr, J. S., & Lüderitz, B. (2003). D-Ribose improves diastolic function and quality of life in congestive heart failure patients: A prospective feasibility study. European Journal of Heart Failure, 5(5), 615-619. doi:10.1016/s1388-9842(03)00060-6

(7) Pauly, D. F., & Pepine, C. J. (2000). D-Ribose as a Supplement for Cardiac Energy Metabolism. Journal of Cardiovascular Pharmacology and Therapeutics, 5(4), 249-258. doi:10.1054/jcpt.2000.18011

(8) Tullson, P. C., John-Alder, H. B., Hood, D. A., & Terjung, R. L. (1988). De novo synthesis of adenine nucleotides in different skeletal muscle fiber types. American Journal of Physiology-Cell Physiology, 255(3). doi:10.1152/ajpcell.1988.255.3.c271

(9) Wyatt, D. (1989). Purine-enriched asanguineous cardioplegia retards adenosine triphosphate degradation during ischemia and improves postischemic ventricular function. J Thoraci Cardiovasc Surg, 97(5):, 771-778. Retrieved July 12, 2018.

(10) Zarzeczny, R., Brault, J. J., Abraham, K. A., Hancock, C. R., & Terjung, R. L. (2001). Influence of ribose on adenine salvage after intense muscle contractions. Journal of Applied Physiology, 91(4), 1775-1781. doi:10.1152/jappl.2001.91.4.1775





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