Research






Our expert nutritionists keep pace with the academic community by examining articles in peer-reviewed journals on topics related to vitamins, science and nutritional supplementation.  Here, our latest research includes articles quoted in our Nutrients A-Z list:



L-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials; American Journal of Pschiatry, Vol. 169 Issue 12; Dec. 2012 pp. 1267-1274.  (14)

Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2011; 2:CD001364. (28)

Kim A, Chiu A, Barone MK, et al. Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J Am Diet Assoc. 2011; 111(11):1720-1729. (36)

Melainie Cameron, Joel J Gagnier, Sigrun Chrubasik.  Herbal therapy for treating rheumatoid arthritis.  Cochrane Musculoskeletal Group, Feb. 2011; DOI: 10.1002/14651858.CD002948.pub2 (44)

Qin LQ1, Xun P, Bujnowski D, Daviglus ML, Van Horn L, Stamler J, He K; INTERMAP Cooperative Research Group. Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults. J Nutr. 2011 Feb; 141(2):249-54. doi: 10.3945/jn.110.128520. Epub 2010 Dec 15. (60)

Hemila H, Chalker E, Douglas B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2010; (3):CD000980 (2)
Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr. 2010; 10:14. (34)

Dae Jung Kim, MD, Pengcheng Xun, MD, PhD, Kiang Liu, PhD, Catherine Loria, PhD, Kuninobu Yokota, MD, PhD, David R. Jacobs Jr., PhD, and Ka He, MD ScD. . Magnesium Intake in Relation to Systemic Inflammation, Insulin Resistance, and the Incidence of Diabetes.   Diabetes Care.  Published online August 31, 2010. (18)

Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med. 2009; 15(8):891-897. (40)

Gaby AR. Nutritional approaches to prevention and treatment of gallstones. Altern Med Rev. 2009; 14(3):258-267. (83)

R. Jorde, et al.  Effects of Vitamin D Supplementation on Symptoms of Depression in Overweight and Obese Subjects; The Journal of Internal Medicine. September 2008 (3)

Bardia A, Tleyjeh IM, Cerhan JR, et al. Efficacy of antioxidant supplementation in reducing primary cancer incidence and mortality: systematic review and meta-analysis. M ayo Clin Proc. 2008; 83:23-34. (24)

Chin SF, Hamid NA, Latiff AA, et al. Reduction of DNA damage in older healthy adults by Tri E® Tocotrienol supplementation.  Nutrition.  2007 Sep 19. (5)

Wang X, Qin X, Demirtas H, et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet. 2007; 369:1876-1882. (11)

World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. 2007. American Institute for Cancer Research, Washington, DC. (15)

Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007; 61(5):343-348. (38)

Whigham LD, Watras AC, Schoeller DA. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr. 2007; 85:1203-1211. (49)

Kimura K, Ozeki M, Juneja LR, Ohira H.  L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007; 74(1):39-45. (67)

Chandra RV, Prabhuji ML, Roopa DA, et al. Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial. Oral Health Prev Dent. 2007; 5:327-336. (85)

Edwards RL, Lyon T, Litwin SE, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007; 137:2405-2411. (87)

Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother. 2006; 5:1-11. (43)

Van Brummelen R, du Toit D.  L-methionine as immune supportive supplement: a clinical evaluation. Amino Acids. 2006 Sep 29 [Epub ahead of print] (62)

Liu J, Zhang J, Shi Y, et al. Chinese red yeast rice (Monascus purpureus ) for primary hyperlipidemia: a meta-analysis of randomized controlled trials. Chin Med. 2006; 1:4. (88)

Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ. 2005; 173:1043-1048. (35)

Sima AA, Calvani M, Mehra M, et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care. 2004; 28:89-94. (53)

Li Q, Guo-Ross S, Lewis DV, Turner D, White AM, Wilson WA, Swartzwelder HS.  Dietary prenatal choline supplementation alters postnatal hippocampal structure and function. J Neurophysiol. 2004 Apr; 91(4):1545-55. (75)
 
Richer S, Stiles W, Statkute L, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry. 2004; 75:216-30. (84)

Usha P.R., Naidu M.U.R. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation. 2004; 24:353-363. (89)

Omran H, Illien S, MacCarter D, et al. D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail. 2003; 5:615-619. (79)

Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q 10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem. 2003; 246:75-82. (47)

Heaney RP. Advances in therapy for osteoporosis. Clin Med Res. 2003; 1:93-9. (21)

Braam LA, Knapen MH, Geusens P, et al.  Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int. 2003; 73:21-26. (6)

Morris MC. Evans DA. Bienias JL. Tangney CC. Wilson RS.  Vitamin E and cognitive decline in older persons.  Archives of Neurology. 59(7):1125-32, 2002 Jul. (4)

Auborn KJ. Therapy for recurrent respiratory papillomatosis. Antivir Ther . 2002; 7:1–9. (78)

Debruyne F, Koch G, Boyle P, et al. Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a one-year randomized international study. Eur Urol. 2002; 41:497-507. (39)

Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry. 2002; 159:477-479. (48)

Vetrugno M. Maino A. Cardia G. Quaranta GM. Cardia L.  A randomized, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy. British Journal of Ophthalmology. 85(5):537-9, 2001, May. (1)

Herbal and dietary therapies for primary and secondary dysmenorrhea. Wilson ML. Murphy PA. Department of Obstetrics and Gynaecology, National Women's Hospital, Claude Road, Epsom, Auckland, New Zealand, 1003. Cochrane Database of Systematic Reviews. (3):CD002124, 2001. (7)

McKinley MC. McNulty H. McPartlin J. Strain JJ. Pentieva K. Ward M. Weir DG. Scott JM. Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete.  American Journal of Clinical Nutrition. 73(4):759-64, 2001 Apr. (10)

Gu D, He J, Wu X, et al. Effect of potassium supplementation on blood pressure in Chinese: a randomized, placebo-controlled trial. J Hypertens. 2001; 19:1325-1331.  (23)

Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001; 18:189-193. (33)
Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol. 2001; 97:577-582. (41)

Merchant RE, Andre CA. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med. 2001; 7:79-80,82-91. (51)

Kanbak G, Inal M, Baycu C. Ethanol-induced hepatotoxicity and protective effect of betaine. Cell Biochem Funct. 2001; 19:281-285. (91)

Chen DZ, Qi M, Auborn KJ, Carter TH. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. J Nutr. 2001; 131:3294–302. (77)

Reginster JY, Deroisy R, Rovati L, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001; 357:251-256. (80)

Palatnik A, Frolov K, Fux M, et al. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol. 2001; 21:335-339. (82)

Hinton PS, Giordano C, Brownlie T, et al. Iron supplementation improves endurance after training in iron-depleted, nonanemic women. J Appl Physiol. 2000; 88:1103-1111. (17)

Goldfine AB, Patti ME, Zuberi L, et al. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. 2000; 49:400-410. (26)

Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000 Dec;7(6):463-9. (29)

Chiou WF, Chang PC, Chou CJ, Chen CF. Protein constituent contributes to the hypotensive and vasorelaxant activities of Cordyceps sinensisLife Sci. 2000; 66:1369-1376. (31)

Agerholm-Larsen L, Raben A, Haulrik N, et al. Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J Clin Nutr. 2000; 54:288-297. (50)

Hambrecht R, Hilbrich, L, Erbs S, et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol. 2000; 35:706-713. (54)

Watanabe G, Tomiyama H, Doba N. Effects of oral administration of L-arginine on renal function in patients with heart failure. J Hypertens. 2000; 18:229-234. (56)

Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis. 2000; 10:49-60. (59)

Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int. 2000; 85:842-846. (73)

Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol . 2000; 78:123-129. (81)

Juneja LR. Suntheanine and its relaxation effect in humans. Trends in Food Science & Tech. 1999; 10; 199-204. (66)

Deijen JB, Wientjes CJ, Vullinghs HF, et al. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res Bull. 1999; 48:203-209. (69)

Schoenen J, Jacquy J, Lenaerts M.  Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology. 1998; 50:466-470. (8)

Polo V, Saibene A, Pontiroli AE. Nicotinamide improves insulin secretion and metabolic control in lean type 2 diabetic patients with secondary failure to sulphonylureas. Acta Diabetol. 1998; 35:61-64. (9)

Kosenko LG. The content of some trace elements in the blood of patients suffering from diabetes mellitus. Klin Med (Mosk). 1964; 42:113-116. In: Werbach MR. Nutritional Influences on Illness: A Sourcebook of Clinical Research [book on CD-ROM]. Tarzana, CA: Third Line Press; 1998. (19)

Zi X, Feyes DK, and Agarwal R. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468. Clin Cancer Res. 1998; 4:1055-1064. (37)

Singh RB, Wander GS, Rastogi A, et al. Randomized double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs Ther. 1998; 12:347-353. (46)

Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage. 1998; 6(suppl A):37-38. (74)

Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes. 1997; 46:1786-1791. (16)

Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA. 1997; 277:1624-1632. (22)

Bone K. Bilberry-The vision herb. MediHerb Prof Rev. 1997; 59:1-4. (30)

Flodin NW. The metabolic roles, pharmacology, and toxicology of lysine. J Am Coll Nutr . 1997; 16:7-21. (61)

De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J. 1997; 10:1535-1541 (70)

Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997; 46(suppl 2):S62-S66. (71)

Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes. 1996; 45:659-666. (25)

Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation. 1996; 93:2135-2141. (55)

Castell LM, Poortmans JR, Newsholme EA. Does glutamine have a role in reducing infections in athletes? Eur J Appl Physiol Occup Physiol. 1996; 73:488-490. (58)

Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol and the liver: a review. Alcohol. 1996; 13:395-398. (90)

van Goor L, Woiski MD, Lagaay AM, et al.  Review: cobalamin deficiency and mental impairment in elderly people. Age Ageing. 1995; 24:536-542. (12)

Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1995; 95:2501-2509. (27)

Neri DF, Wiegmann D, Stanny RR, et al. The effects of tyrosine on cognitive performance during extended wakefulness. Avit Space Environ Med. 1995; 66:313-319. (68)

Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995; 345:1529-1532. (72)

Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther . 1994; 8:659-664. (42)

Galley P, Thiollet M. A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility. Int Angiol . 1993; 12:69-72. (76)

Cenacchi T, Bertoldin T, Farina C, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano). 1993; 5:123-133. (86)

Pennypacker LC, Allen RH, Kelly JP, et al. High prevalence of cobalamin deficiency in elderly outpatients. J Am Geriatr Soc. 1992; 40:1197-1204. (13)

Collisson RJ. Siberian ginseng (Eleutherococcus senticosus). Brit J Phytother. 1991; 2:61-71 [review]. (32)

Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: Serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology. 1991; 24:53-81. (52)

Cacciatore L, Cerio R, Ciarimboli M, et al. The therapeutic effect of L-carnitine in patients with exercise-induced stable angina: a controlled study. Drugs Exp Clin Res. 1991; 17:225-235. (57)

Azuma J, Sawamura A, Awata N, et al. Double-blind randomized crossover trial of taurine in congestive heart failure. Curr Ther Res. 1983; 34:543-557. (65)

Beckmann H, Athen D, Olteanu M, et al. DL-phenylalanine versus imipramine: a double-blind controlled study. Arch Psychiat Nervenkr. 1979; 227:49-58. (64)

Heller B. Pharmacological and clinical effects of D-phenylalanine in depression and Parkinson’s disease. In: Mosnaim AD, Wolf ME, eds. Noncatecholic Phenylethylamines . Part 1. New York, NY: Marcel Dekker; 1978:397-417. (63)

Ryan RE. A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache. 1967; 7:13-17. (45)

Kosenko LG. The content of some trace elements in the blood of patients suffering from diabetes mellitus. Klin Med (Mosk). 1964; 42:113-116. (20)

 
 
 
 
 
 
 
 
 
 
 


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